The distance between Azambuja and Santarém is around 33 km and can be covered in approximately 8 hours. 

The Route continues into the heart of the Lezíria do Tejo, a territory predominantly made up of irrigated plains fostering fertile agricultural land. This floodplain landscape is often compartmentalised by native hedge species. 

Lined with leafy ash trees overshadowing the banks, many pleasant river beaches emerge along the banks of the river. Cyclical flooding alters the banks of the river and its tributaries, giving rise to the construction of the dykes that characterise many local villages, such as Valada do Ribatejo, Reguengo do Alviela and Porto de Muge.